Acquired: Chambers was selected in the first round (6th overall) by the Eskimos in the 2012 CFL Canadian Draft.

2012: (Edmonton) Chambers played in 16 games (11 starts) and recorded 37 catches for 390 yards and two touchdowns. His first CFL touchdown came at home against Winnipeg on July 13. Chambers started the Eastern Division semifinal and had two catches for 16 yards. He spent the first game of the season on the 1-Game Injured List and Week 6 on the reserve list. He switched his jersey number from no.88 to no.17 before Week 5 against Winnipeg to honour his brother Jonathan, who passed away at the age of 17. Chambers was the Eskimos nominee for the CFL's Most Outstanding Rookie of the Year.

College/Personal: Chambers played his college football at Wilfrid Laurier University for the Golden Hawks. He received OUA Men’s football Second Team All-Star honours in 2008, 2010, and 2011. In 37 career games with the Golden Hawks he recorded 151 receptions for 2,068 yards, 18 touchdowns, and five tackles. He spent time on the return game as well, returning 26 kick-offs for 587 yards and one touchdown; as well as 27 punt returns for 237 yards. Chambers showed his speed off at the CFL Combine; he ran a 4.42, 40-yard dash which was the fastest recorded time. He attended a Philadelphia Eagles mini-camp in May 2012.